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GAF SDS # 2093 <br /> Eyes: May cause irritation to the eyes if dust is generated. <br /> Skin: May cause irritation to the skin if dust is generated. <br /> Ingestion: This product is not intended to be ingested, If ingested, it may <br /> cause temporary irritation to the gastrointestinal (digestive) tract. <br /> Inhalation: May cause irritation to the respiratory tract. <br /> ACUTE HEALTH HAZARDS: NIOSH has found that studies of workers exposed to asphalt <br /> fumes have repeatedly found irritation of the serous membranes <br /> of the conjunctivae (eye irritation)and the mucous membranes of <br /> the upper respiratory tract(nasal and throat irritation). <br /> CHRONIC HEALTH HAZARDS: Studies in humans have found that exposure to respirable <br /> crystalline silica (quartz)can cause silicosis, a fibrosis (scarring) <br /> of the lungs. Silicosis is a serious and irreversible disease; it may <br /> be progressive even after exposure has ceased; it can lead to <br /> disability and death. Human studies also have found that silicosis <br /> is a risk factor for tuberculosis, and that occupational exposure to <br /> respirable crystalline silica is associated with chronic obstructive <br /> pulmonary disease, including bronchitis and emphysema. Some <br /> studies show excess numbers of cases of scleroderma, <br /> connective tissue disorders, lupus, rheumatoid arthritis, chronic <br /> kidney diseases and end-stage kidney disease in workers <br /> exposed to respirable crystalline silica. <br /> CARCINOGENICITY: IARC has determined that occupational exposure to oxidized <br /> asphalt and its emissions is probably carcinogenic to humans <br /> (Group 2A). IARC concluded that available data from cancer <br /> studies in humans points to an association between exposures to <br /> oxidized asphalts during roofing and lung cancer and tumors in <br /> the upper aero-digestive tract. In addition, IARC found sufficient <br /> evidence of carcinogenicity in experimental animals for extracts <br /> and fume condensates of oxidized asphalts. <br /> NIOSH has concluded that the collective data from human, <br /> animal, genotoxicity and exposure studies provide sufficient <br /> evidence that roofing asphalt fumes are a potential occupational <br /> carcinogen. <br /> Occupational exposure to respirable crystalline silica is classified <br /> as a known carcinogen in humans. IARC has determined that <br /> respirable crystalline silica is carcinogenic to humans (Group 1), <br /> based on findings of sufficient evidence of carcinogenicity in both <br /> humans and experimental animals. NTP has classified respirable <br /> crystalline silica as a known human carcinogen based on <br /> sufficient evidence of carcinogenicity from studies in humans <br /> indicating a causal relationship between exposure to respirable <br /> crystalline silica and increased lung cancer rates in workers <br /> exposed to crystalline silica dust. NIOSH has determined that <br /> respirable crystalline silica is a potential occupational carcinogen. <br /> IARC has determined that occupational exposure to Titanium <br /> Dioxide is possibly carcinogenic to humans (Group 213). IARC <br /> concluded lung tumors were observed in rats following high dose <br /> exposure by inhalation and in female rats exposed by intra- <br /> Page 2 of 7 <br />