Laserfiche WebLink
..,,. ._ _.. FROM ' �=,a�1 <br />TO �r120625BEd�3- P.68 <br />CtiY�ON �NCl�1 Dl�t�l Pa� 7 O! � <br />��.,� ��� <br />p�IG1, �lOIiCITl: <br />Tht deTm�l tD50 in rabbit� !i > 5 M1Ikq. <br />•tp' i �7'ORI / I �OIILLS I CM : <br />No ptoduet toxieolo9Y dat• ��a:labin. The nazard �valuation wa� b�a�d en <br />dita [fan aimiltC mtk�rSala. <br />1116tfR ION s <br />Th� oral LD60 in rats i• > 6 ml/kg. <br />1�DDITIOIiAL TO%ICOL08Y DA'�A� <br />Tht daea abov� is obLain�d from �tudies oponror�d by the um�rican <br />P�trolaum Inflitut� (ADI1. <br />12. ADDITIOII�L Fa1�LT8 D►T71 <br />11DOit10N�L riLL?H D11l1 COMRM!'t <br />Thi� prodvet eontaiai � mix�ure oi p�irol�um hydroeerbons e�11ad middle <br />QisLill�t�r (rhieh m�an� lh�y boil b��w�n approximstely 360i an1 700!). <br />diatillaLesty�t lA�Ydaa�,Produ��drbyaaYvarl�ty�ofadSifer�nil•p irol�ume <br />r�iininq proee�s�s. ToXieoloqY d�t� d�veloped on �om� miCdle Ci�eillices <br />found lhai thay eau��d Dositive re�poasas in som� mutaq�nieity t��ta �nd <br />cau��d ikin eaneer vh�n r�p�ata�lly �DDli�d to mic� ov�r ih�ir Sifetim�. <br />Thit produet m�r eont�f.n som� m:ddie dlstillatea found to e�uae tho�• <br />adverse eff�et�. <br />This prWuct cone�ins napt:ih�l�ne. ov�r�xDo�ura to loduca,�i�niband <br />inh�latioa o! v�por. inqsrtion or akin cont�et m�Y P 9 <br />�ymptoms of h��daeh�, fav�:, Drotu�e sv�atiaQ, nsusea, abdominal pain, <br />di�rrh�a, lethargY, eramors, eonvu;siens, ��id�nea of blood eh�nqe�, <br />ineludlnq h�maburia and h�saoglobinnria, and opele nauritis. L�boraeory <br />animal� qiv�n rep�al�d oral do��� of n�phthaleM h�ve a��.li�aa�in�.i.�t:. <br />MEDICAL �ONDITIONB AOOIt�VATLD DY LXPOB�IR6 TO NAPRTN1�L�ti6= <br />vith conq�nitsl eryLhroeYte qlueos�-6-phosphat• d�tydroqanase d�lieSaney <br />may be D�=xieularly �uaeaptible !o th� hamolytic •if�cta ot the <br />naphthelar.r. <br />Hheie di��al �nqine �xhwst v�s r�v1�r�Q by th� int�rnaiionsl Agency fer <br />R�a�areh on C�ne�r (iLAC) in lheir Mono9r�Dh �6 (1909). Lvilenee fo: <br />IaRCiplaeaflCC1���1 �xhauit=in eateporrnZAineonsi8erinqd!liprobabiy humanr. <br />caCcino9�nie to hum�ns. <br />The Netlonal Inetitut� of OccuD�Lionel Saf�ty and ltealth (ttI08M) ha� <br />reoomm�nded thet rhola diea�l �xlfaust be r�9�sdad es pot�ntlally aeu�ing <br />csnc�r. This r�commendetion �u ba�ed on t�st result� shovinp iner�aa�d <br />luh9 eancer in laboratoTY animais exDosad to vhol� dl�ial �xhatist. The <br />�xe�sa ri�k of eanaer tor p�opl� exDoo�d to Qi���l axhaust ha� not been <br />d�termined a� aLudles on �xpo��d vork�rs heve b��n Sneonelu�iv;,. 2e !s <br />r�eommend�d th�t expo�ur� Lo Cit��l �xhausL be minlmisad to r�due� the <br />pol�nlisl cene�r ri�k. <br />���� <br />R�ti!!oo Mtl�t� d Aa�i�lOe D�t�: 0!/3a/!0 MaDi Mu�rs 001�ld <br />NDA - Mo 6�t� 1►�dlabU IIa - Met 1►Prlieabl� <br />