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contaminant level (MCL) at a concentration of 4 mg/L or parts per million(ppm).5 The <br /> MCL is an enforceable standard. Aside from federal enforcement of the MCL, the level <br /> of fluoridation is determined at the local level, generally this practice uses fluoride at <br /> approximately 1 ppm. In 1991, the Public Health Service reaffirmed optimal fluoridation <br /> of water concentration of 0.7 -1.2 mg/L.6 The NRC, a branch of the National Academy of <br /> Sciences, reviewed the health effects of fluoride and found the EPA's MCL of 4 mg/L to <br /> be an appropriate interim standard,but further research regarding exposure and toxicity <br /> were recommended in 1993.7 <br /> 2006 NRC Report: Fluoride in Drinking Water: The major conclusion of the 507- <br /> page NRC Scientific Review of EPA's Standards is relevant to the entire population <br /> (page 2 paragraph 4), "After reviewing the collective evidence, including studies <br /> conducted since the early 1990s, the committee concluded unanimously that the present <br /> MCLG of 4 mg/L for fluoride should be lowered." The potential health risks are skeletal <br /> fluorosis,bone fractures and severe enamel fluorosis, which may increase the risk of <br /> dental decay. Another conclusion is important for individuals with chronic kidney disease <br /> (CKD),page 9,paragraph 1, "However, a potentially susceptible subpopulation <br /> comprises individuals with renal impairments who retain more fluoride than healthy <br /> people do." The EPA is evaluating how to best implement the fmdings of this report. <br /> Note that reduction of the MCLG of 4 ppm would not affect the practice of fluoridation <br /> of water at approximately 1 ppm. <br /> Fluoride Health Benefits: The major benefit of water and dental products containing <br /> fluoride is the prevention of dental caries in people of all ages. This has been recognized <br /> by the US Public Health Service since at least 1950. The Centers for Disease Control and <br /> Prevention, the World Health Organization and other respected health organizations also <br /> promote water fluoridation. Increasing the proportion of the U.S. populations served by <br /> community water systems with optimally fluoridated water is a goal of Healthy People <br /> 2010.8 Mechanisms through which fluoride provides this benefit include a systemic effect <br /> due to the replacement of hydroxyl ions in hydroxapatite by fluoride ions during tooth <br /> development in children during enamel formation, a topical effect to remineralize teeth <br /> after bacterial demineralization, and a topical effect to inhibit bacterial acid release.9"° <br /> Fluoride Exposure: The major sources of fluoride are water, dental products, and diet. <br /> Rarely, drugs and inhalation are significant sources. Approximately 67 % of public US <br /> water systems deliver optimally fluoridated water(0.7— 1.2 ppm).11 Soduim fluoride, <br /> sodium fluorosilicate, and fluorosilic acid are added to the water systems. Public water <br /> systems in the US serving about 1.6 million people have naturally occurring levels that <br /> significantly exceed this optimal concentration recommendation. The majority of bottled <br /> water,which unlike drinking water is regulated by FDA, contains low levels of fluoride, <br /> although there may be significant variation depending on the source. Toothpaste sources <br /> contain approximately 1,000 fold more fluoride or 1,000 to 1,500 ppm,which may be a <br /> significant source of exposure for individuals with inability to control the swallowing <br /> reflex such as children under age 6 years. Of course the level of fluoride in water used to <br /> prepare food and beverages will be reflected in the product. Exposure from food and <br /> beverages is difficult to monitor, since FDA food labels do not quantify fluoride content. <br />