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Nine accidents involving the introduction of excess fluoride into <br /> community water supplies in the United States have been reported during <br /> the 'last decade. In all but one of these accidents, .only a small proportion <br /> of the population became 11l with mild transient gastrointestinal symptoms. <br /> After a spillage accident in Annapolis, Maryland in 1979, in which the <br /> fluoride concentration of tap water reached 50 times the recommended level, <br /> only a small percentage of the total population exposed became ill with <br /> gastrointestinal symptoms. However, for eight persons who were undergoing <br /> artificial kidney treatments at the time, the use of the high-fluoride <br /> water in preparation of the dialysate resulted in a marked elevation of <br /> serum concentrations of fluoride and symptoms of fluoride intoxication. <br /> In addition, one patient suffered a cardiorespiratory arrest which was <br /> reversible and another patient, died within 24 hours of exposure, which <br /> presumably also was related to acute fluoride intoxication.5 _ <br /> It is recommended that (1) for patients undergoing long term dialysis; <br /> water used- for preparation of dialysate be treated and appropriately monitored <br /> according to the AAMI proposed standards for hemodialysis systems.6 In <br /> addition, (2) water treatment officials should develop and maintain emergency <br /> plans so that susceptible individuals and health officials are promptly <br /> notified of the occurrence of any situations involving water used for dialysis <br /> which may pose a major health risk. (3) Fluoride concentration monitoring <br /> at water treatment plants should be capable of detecting the actual fluoride <br /> levels directly. (4) It would also seem prudent to monitor the fluoride <br /> intake of patients with chronic renal impairment, particularly those living <br /> in areas of high naturally occurring fluoride, children, those with excessive <br /> fluoride intake, and those with prolonged disease. There is insufficient <br /> evidence at this time to recommend the use of fluoride-free drinking water <br /> for all patients with renal disease. <br />